Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Enzymes are biocatalysts that speed up the chemical reaction to obtain the final valuable
product/s. Biotechnology has revolutionized the use of traditional enzymes to be applicable …

Hijacking the cellular protein degradation system offers unique opportunities for drug
discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for …

The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

Non-model microorganisms often possess complex phenotypes that could be important for
the future of biofuel and chemical production. They have received significant interest the last …

Metabolic engineering holds the promise to transform the chemical industry and to support
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …

Pseudomonas putida is a microbial chassis of huge potential for industrial and
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …

Living organisms evolve complex genetic networks to interact with the environment. Due to
the rapid development of synthetic biology, various modularized genetic parts and units …

Being the green gold of the future, microalgae and cyanobacteria have recently attracted
considerable interest worldwide, for their metabolites such as lipids, protein, pigments, and …

CRISPR interference (CRISPRi) is the leading technique to silence gene expression in
bacteria; however, design rules remain poorly defined. We develop a best-in-class …