The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Background Weight loss is often key in the management of obese or overweight patients
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …

Because human energy metabolism evolved to favor adiposity over leanness, the
availability of palatable, easily attainable, and calorically dense foods has led to …

Although promising therapeutics are in the pipeline, bariatric surgery (also known as
metabolic surgery) remains our most effective strategy for the treatment of obesity and type 2 …

Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

The worldwide obesity epidemic continues unabated, adversely impacting upon global
health and economies. People with severe obesity suffer the greatest adverse health …

Two of the most popular bariatric procedures, vertical sleeve gastrectomy (VSG) and Roux-
en-Y gastric bypass (RYGB), are commonly considered metabolic surgeries because they …

Bariatric surgery for obesity has proved to be an extremely effective method of promoting
long-term weight reduction with additional beneficial metabolic effects, such as improved …

Gastric bypass surgery leads to profound changes in the secretion of gut hormones with
effects on metabolism, appetite, and food intake. Here, we discuss their contributions to the …