Leveraging the replication stress response to optimize cancer therapy
E Cybulla, A Vindigni - Nature Reviews Cancer, 2023 - nature.com
High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …
Small-molecule modulation of protein homeostasis
GM Burslem, CM Crews - Chemical reviews, 2017 - ACS Publications
Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …
research tool but lacks the advantages of small molecules with respect to cell permeability …
Pharmacological modulation of ubiquitin-proteasome pathways in oncogenic signaling
The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
[HTML][HTML] Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma
Abstract MicroRNA-9 (miR-9) dysregulation is implicated in a variety of human malignancies
including hepatocellular carcinoma (HCC), but its role remains contradictory. In this study …
including hepatocellular carcinoma (HCC), but its role remains contradictory. In this study …
Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
Signaling pathways control cell fate decisions that ultimately determine the behavior of
cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant …
cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant …
Biomarkers for early detection, prognosis, and therapeutics of esophageal cancers
Esophageal cancer (EC) is the deadliest cancer worldwide, with a 92% annual mortality rate
per incidence. Esophageal squamous cell carcinoma (ESCC) and esophageal …
per incidence. Esophageal squamous cell carcinoma (ESCC) and esophageal …
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs
P Xu, Z Liu, Y Liu, H Ma, Y Xu, Y Bao, S Zhu… - Nature …, 2021 - nature.com
Canonical CRISPR–knockout (KO) screens rely on Cas9-induced DNA double-strand
breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted …
breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted …
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer
K Davalieva, IM Kostovska, S Kiprijanovska… - The …, 2015 - Wiley Online Library
BACKGROUND The key to a more effective diagnosis, prognosis, and therapeutic
management of prostate cancer (PCa) could lie in the direct analysis of cancer tissue. In this …
management of prostate cancer (PCa) could lie in the direct analysis of cancer tissue. In this …
A patent review of the ubiquitin ligase system: 2015–2018
Introduction: Ubiquitin-proteasome system (UPS) has been validated as a novel anticancer
drug target in the past 20 years. The UPS contains two distinct steps: ubiquitination of a …
drug target in the past 20 years. The UPS contains two distinct steps: ubiquitination of a …
[HTML][HTML] Ubc13: the Lys63 ubiquitin chain building machine
Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …