Despite numerous viral outbreaks in the last decade, including a devastating global
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …

Powassan virus is an increasingly-recognized cause of severe encephalitis that is
transmitted by Ixodes ticks. Given the nonspecific clinical, laboratory, and imaging features …

SARS-CoV-2 distribution and circulation dynamics are not well understood due to
challenges in assessing genomic data from tissue samples. We develop experimental and …

Encephalitis is a devastating neurologic disease often complicated by prolonged neurologic
deficits. Best practices for the management of adult patients include universal testing for a …

The family Flaviviridae is comprised of a diverse group of arthropod-borne viruses that are
the etiological agents of globally relevant diseases in humans. Among these, infection with …

The burden of ticks and the pathogens they carry is increasing worldwide. Powassan virus
(POWV; Flaviviridae: Flavivirus), the only known North American tick-borne flavivirus, is of …

Viral diseases have emerged as a serious threat to humanity and as a leading cause of
morbidity worldwide. Many viral diagnostic methods and antiviral therapies have been …

Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the
northeastern United States, with a 2% prevalence in Long Island (LI) deer ticks (Ixodes …

Dear Editor, Patients with chronic lymphocytic leukemia (CLL) are at increased risk for
infection due to immunosuppression that is both intrinsic to the disease and secondary to …

The genetic diversities of mammalian tick-borne flaviviruses are poorly understood. We used
next-generation sequencing (NGS) to deep sequence different viruses and strains …