[HTML][HTML] Advances in antibody phage display technology

L Ledsgaard, A Ljungars, C Rimbault, CV Sørensen… - Drug Discovery …, 2022 - Elsevier
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …

Is there new hope for therapeutic matrix metalloproteinase inhibition?

RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

H He, B He, L Guan, Y Zhao, F Jiang, G Chen… - Nature …, 2024 - nature.com
Artificial Intelligence (AI) techniques have made great advances in assisting antibody
design. However, antibody design still heavily relies on isolating antigen-specific antibodies …

Phage display-derived human antibodies in clinical development and therapy

A Frenzel, T Schirrmann, M Hust - MAbs, 2016 - Taylor & Francis
Over the last 3 decades, monoclonal antibodies have become the most important class of
therapeutic biologicals on the market. Development of therapeutic antibodies was …

Antibody display technologies: selecting the cream of the crop

B Valldorf, SC Hinz, G Russo, L Pekar, L Mohr… - Biological …, 2022 - degruyter.com
Antibody display technologies enable the successful isolation of antigen-specific antibodies
with therapeutic potential. The key feature that facilitates the selection of an antibody with …

Monoclonal antibody therapeutics: history and future

NAPS Buss, SJ Henderson, M McFarlane… - Current opinion in …, 2012 - Elsevier
Over the last three decades, monoclonal antibodies have made a dramatic transformation
from scientific tools to powerful human therapeutics. At present, approximately 30 …

Electrochemical sensors to detect bacterial foodborne pathogens

LM Castle, DA Schuh, EE Reynolds, AL Furst - ACS sensors, 2021 - ACS Publications
Bacterial foodborne pathogens cause millions of illnesses each year and disproportionately
impact those in developing countries. To combat these diseases and their spread, effective …

Sensitive detection of dengue virus type 2 E-proteins signals using self-assembled monolayers/reduced graphene oxide-PAMAM dendrimer thin film-SPR optical …

NAS Omar, YW Fen, J Abdullah, Y Mustapha Kamil… - Scientific reports, 2020 - nature.com
In this work, sensitive detection of dengue virus type 2 E-proteins (DENV-2 E-proteins) was
performed in the range of 0.08 pM to 0.5 pM. The successful DENV detection at very low …

Selecting and screening recombinant antibody libraries

HR Hoogenboom - Nature biotechnology, 2005 - nature.com
During the past decade several display methods and other library screening techniques
have been developed for isolating monoclonal antibodies (mAbs) from large collections of …

An improved yeast transformation method for the generation of very large human antibody libraries

L Benatuil, JM Perez, J Belk… - … Engineering, Design & …, 2010 - academic.oup.com
Antibody library selection by yeast display technology is an efficient and highly sensitive
method to identify binders to target antigens. This powerful selection tool, however, is often …