Emerging role of glioma stem cells in mechanisms of therapy resistance

F Eckerdt, LC Platanias - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma is among the most lethal cancers in humans. Glioblastomas
exhibit a striking heterogeneity, which is maintained by a highly plastic, adaptable …

Intra-operative applications of augmented reality in glioma surgery: a systematic review

A Ragnhildstveit, C Li, MH Zimmerman… - Frontiers in …, 2023 - frontiersin.org
Background Augmented reality (AR) is increasingly being explored in neurosurgical
practice. By visualizing patient-specific, three-dimensional (3D) models in real time …

White matter tract density index prediction model of overall survival in Glioblastoma

A Salvalaggio, L Pini, M Gaiola, A Velco… - JAMA …, 2023 - jamanetwork.com
Importance The prognosis of overall survival (OS) in patients with glioblastoma (GBM) may
depend on the underlying structural connectivity of the brain. Objective To examine the …

Transcriptomic and connectomic correlates of differential spatial patterning among gliomas

R Romero-Garcia, AS Mandal, RAI Bethlehem… - Brain, 2023 - academic.oup.com
Unravelling the complex events driving grade-specific spatial distribution of brain tumour
occurrence requires rich datasets from both healthy individuals and patients. Here, we …

Regional healthy brain activity, glioma occurrence and symptomatology

T Numan, LC Breedt, BAPC Maciel, SD Kulik, J Derks… - Brain, 2022 - academic.oup.com
It is unclear why exactly gliomas show preferential occurrence in certain brain areas.
Increased spiking activity around gliomas leads to faster tumour growth in animal models …

The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia

E Macdonald-Laurs, AEL Warren, P Francis… - Brain, 2024 - academic.oup.com
Bottom-of-sulcus dysplasia (BOSD) is increasingly recognized as a cause of drug-resistant,
surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe …

Structural connectome quantifies tumour invasion and predicts survival in glioblastoma patients

Y Wei, C Li, Z Cui, RC Mayrand, J Zou, ALKC Wong… - Brain, 2023 - academic.oup.com
Glioblastoma is characterized by diffuse infiltration into the surrounding tissue along white
matter tracts. Identifying the invisible tumour invasion beyond focal lesion promises more …

White matter tracts and diffuse lower-grade gliomas: the pivotal role of myelin plasticity in the tumor pathogenesis, infiltration patterns, functional consequences and …

H Duffau - Frontiers in Oncology, 2022 - frontiersin.org
For many decades, interactions between diffuse lower-grade glioma (LGG) and brain
connectome were neglected. However, the neoplasm progression is intimately linked to its …

Brain network mapping and glioma pathophysiology

AS Mandal, S Brem, J Suckling - Brain Communications, 2023 - academic.oup.com
Adult diffuse gliomas are among the most difficult brain disorders to treat in part due to a lack
of clarity regarding the anatomical origins and mechanisms of migration of the tumours …

Glioblastoma and brain connectivity: the need for a paradigm shift

A Salvalaggio, L Pini, A Bertoldo… - The Lancet Neurology, 2024 - thelancet.com
Despite substantial advances in cancer treatment, for patients with glioblastoma prognosis
remains bleak. The emerging field of cancer neuroscience reveals intricate functional …