Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to
microenvironmental cues and require strict control of effector functions. Here we showed that …

Current Influenza A virus (IAV) vaccines, which primarily aim to generate neutralizing
antibodies against the major surface proteins of specific IAV strains predicted to circulate …

T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent
T helper cells capable of influencing B cell responses in lymphoid tissues. In physiology, for …

Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate
numerous cellular processes; yet, their contributions to individual effector T cell responses …

The Ikaros zinc-finger transcription factor Eos has largely been associated with sustaining
the immunosuppressive functions of regulatory T cells. Paradoxically, Eos has more recently …

Cytotoxic CD4 T cell effectors (ThCTLs) kill virus-infected major histocompatibility complex
(MHC) class II+ cells, contributing to viral clearance. We identify key factors by which …

+ T helper cells function as critical coordinators of the adaptive immune response through
their ability to differentiate into specific effector subsets that secrete cytokines and aid in the …

The IKAROS family of transcription factors comprises four zinc-finger proteins (IKAROS,
HELIOS, AIOLOS, and EOS), which over the last decades have been established to be …

The dynamic interplay between cellular immunity and tumor cells is essential in cancer
advancement and response to therapy. This updated, comprehensive review examines the …

Background Retroviruses are efficient tools for delivering heritable genes into the genome of
dividing cells. However, conventional NIH-3T3 based retroviral packaging cell lines have …