Biomechanical properties of red blood cells in health and disease towards microfluidics

G Tomaiuolo - Biomicrofluidics, 2014 - pubs.aip.org
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to
navigate across various human microcirculation vessels, enabling them to pass through …

Recent advances in microfluidic techniques for single-cell biophysical characterization

Y Zheng, J Nguyen, Y Wei, Y Sun - Lab on a Chip, 2013 - pubs.rsc.org
Biophysical (mechanical and electrical) properties of living cells have been proven to play
important roles in the regulation of various biological activities at the molecular and cellular …

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

MB Jiménez-Díaz, D Ebert, Y Salinas… - Proceedings of the …, 2014 - National Acad Sciences
Drug discovery for malaria has been transformed in the last 5 years by the discovery of many
new lead compounds identified by phenotypic screening. The process of developing these …

Advances in the measurement of red blood cell deformability: A brief review

J Kim, HY Lee, S Shin - Journal of Cellular Biotechnology, 2015 - content.iospress.com
Red blood cells (RBCs) exhibit a unique deformability, which enables them to change shape
reversibly in response to an external force. The deformability of RBCs allows them to flow in …

Micro total analysis systems: fundamental advances and applications in the laboratory, clinic, and field

ML Kovarik, DM Ornoff, AT Melvin, NC Dobes… - Analytical …, 2013 - ACS Publications
Assay devices designed for these applications offer improvements to existing methods or
provide fundamentally new strategies. Both mature methods and novel techniques have …

Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization

J Chen, C Xue, Y Zhao, D Chen, MH Wu… - International journal of …, 2015 - mdpi.com
This article reviews recent developments in microfluidic impedance flow cytometry for high-
throughput electrical property characterization of single cells. Four major perspectives of …

Cells under stress: an inertial-shear microfluidic determination of cell behavior

FJ Armistead, JG De Pablo, H Gadêlha, SA Peyman… - Biophysical journal, 2019 - cell.com
The deformability of a cell is the direct result of a complex interplay between the different
constituent elements at the subcellular level, coupling a wide range of mechanical …

Microfluidic micropipette aspiration for measuring the deformability of single cells

Q Guo, S Park, H Ma - Lab on a Chip, 2012 - pubs.rsc.org
We present a microfluidic technique for measuring the deformability of single cells using the
pressure required to deform such cells through micrometre-scale tapered constrictions. Our …

Hydrodynamics in cell studies

D Huber, A Oskooei, X Casadevall i Solvas… - Chemical …, 2018 - ACS Publications
Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channels

LM Lee, AP Liu - Lab on a Chip, 2015 - pubs.rsc.org
Micropipette aspiration measures the mechanical properties of single cells. A traditional
micropipette aspiration system requires a bulky infrastructure and has a low throughput and …