Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …

OBJECTIVES: The beneficial effects of ozone therapy consist mainly of the promotion of
blood circulation: peripheral and central ischemia, immunomodulatory effect, energy boost …

In spite of considerable progress that has been reached in understanding how reactive
oxygen species (ROS) interact with its cellular targets, several important challenges …

Review paper attempts to explain the dynamic aspects of redox signaling in aging through
autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states …

In humans, associative memories are more susceptible to age‐related cognitive decline
(ARCD) than are recognition memories. Reduced cAMP/cGMP signaling in the …

Aging-induced neurodegenerative diseases (NDs) are significantly increasing health
problem worldwide. It has been well documented that oxidative stress is one of the potential …

The gut-brain axis plays an important role in Parkinson's disease (PD) by acting as a route
for vagal propagation of aggregated α-synuclein in the gut-first endophenotype and as a …

Pearls have been used in traditional Chinese medicine for the treatment of myopia, epilepsy,
and palpitations. We previously demonstrated that the intraperitoneal administration of nacre …