Precise assembly of proteins and carbohydrates for next-generation biomaterials

L Li, G Chen - Journal of the American Chemical Society, 2022 - ACS Publications
The complexity and diversity of biomacromolecules make them a unique class of building
blocks for generating precise assemblies. They are particularly available to a new …

Mimicking complex biological membranes and their programmable glycan ligands with dendrimersomes and glycodendrimersomes

SE Sherman, Q Xiao, V Percec - Chemical reviews, 2017 - ACS Publications
Synthetic vesicles have been assembled and coassembled from phospholipids, their
modified versions, and other single amphiphiles into liposomes, and from block copolymers …

Targeted and equally distributed delivery of mrna to organs with pentaerythritol-based one-component ionizable amphiphilic janus dendrimers

J Lu, EN Atochina-Vasserman, DS Maurya… - Journal of the …, 2023 - ACS Publications
Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer delivery systems for mRNA

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …

The unexpected importance of the primary structure of the hydrophobic part of one-component ionizable amphiphilic Janus dendrimers in targeted mRNA delivery …

D Zhang, EN Atochina-Vasserman, J Lu… - Journal of the …, 2022 - ACS Publications
Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by
aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to …

Targeted delivery of mRNA with one-component ionizable amphiphilic Janus dendrimers

D Zhang, EN Atochina-Vasserman… - Journal of the …, 2021 - ACS Publications
Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step
of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems …

An introduction to the sugar code

HJ Gabius, J Roth - Histochemistry and cell biology, 2017 - Springer
Carbohydrates have physiological importance far beyond their roles as source of energy
(glycolysis) and activated hydrogen for synthesis (pentosephosphate pathway) or as …

[HTML][HTML] Properties and bioapplications of amphiphilic janus dendrimers: A Review

A Căta, IMC Ienașcu, MN Ştefănuț, D Roșu, OR Pop - Pharmaceutics, 2023 - mdpi.com
Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and
hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent …

Self-assembly of glycerol-amphiphilic Janus dendrimers amplifies and indicates principles for the selection of stereochemistry by biological membranes

D Zhang, Q Xiao, M Rahimzadeh, M Liu… - Journal of the …, 2023 - ACS Publications
The principles for the selection of the stereochemistry of phospholipids of biological
membranes remain unclear and continue to be debated. Therefore, any new experiments on …

Role of globotriaosylceramide in physiology and pathology

AB Celi, J Goldstein, MV Rosato-Siri… - Frontiers in Molecular …, 2022 - frontiersin.org
At first glance, the biological function of globoside (Gb) clusters appears to be that of
glycosphingolipid (GSL) receptors for bacterial toxins that mediate host-pathogen …