Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases
that are characterized by widespread epidermal necrosis and sloughing of skin. They are …

The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

During the past decade, major advances have been made in the accurate diagnosis of
severe cutaneous adverse reactions (SCARs) to drugs, management of their manifestations …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-
interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein …

Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by
translocating to the plasma membrane and inducing its rupture. The activation of MLKL …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Cell death is an essential process that plays a vital role in restoring and maintaining skin
homeostasis. It supports recovery from acute injury and infection and regulates barrier …

Necroptosis was initially identified as a backup cell death program when apoptosis is
blocked. However, it is now recognized as a cellular defense mechanism against infections …