Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …

As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their
own replication. Viruses often co-opt these cellular pathways and processes through …

Mitochondrial fitness is governed by mitochondrial quality control pathways comprising
mitochondrial dynamics and mitochondrial-selective autophagy (mitophagy). Disruption of …

Zika virus (ZIKV) was first isolated in 1947. From its isolation until 2007, symptoms of ZIKV-
caused disease were limited (eg, fever, hives, and headache); however, during the epidemic …

Zika virus (ZIKV) remains a global public health threat with the potential risk of a future
outbreak. Since viral infections are known to exploit mitochondria-mediated cellular …

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in
human populations. ZIKV infection leads to the accumulation of small non-coding viral RNAs …

Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that can have devastating health
consequences. The developmental and neurological effects of a ZIKV infection arise in part …

Macroautophagy/autophagy is increasingly implicated in a variety of diseases, making it an
attractive therapeutic target. However, many aspects of autophagy are not fully understood …

Mitochondria are important organelles involved in cell metabolism and programmed cell
death in eukaryotic cells and are closely related to the innate immunity of host cells against …

Currently, there are no specific therapeutics for flavivirus infections, including dengue virus
(DENV) and Zika virus (ZIKV). In this study, we evaluated extracts from the plants Hedyotis …