Trends in droplet microfluidics: From droplet generation to biomedical applications

Z Chen, S Kheiri, EWK Young, E Kumacheva - Langmuir, 2022 - ACS Publications
Over the past decade, droplet microfluidics has attracted growing interest in biology,
medicine, and engineering. In this feature article, we review the advances in droplet …

Stem cell-based bone and dental regeneration: a view of microenvironmental modulation

C Zheng, J Chen, S Liu, Y Jin - International Journal of Oral Science, 2019 - nature.com
In modern medicine, bone and dental loss and defects are common and widespread
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …

Alginate/laponite hydrogel microspheres co-encapsulating dental pulp stem cells and VEGF for endodontic regeneration

R Zhang, L Xie, H Wu, T Yang, Q Zhang, Y Tian, Y Liu… - Acta biomaterialia, 2020 - Elsevier
Considering the complicated and irregular anatomical structure of root canal systems,
injectable microspheres have received considerable attention as cell carriers in endodontic …

Advanced bottom‐up engineering of living architectures

VM Gaspar, P Lavrador, J Borges… - Advanced …, 2020 - Wiley Online Library
Bottom‐up tissue engineering is a promising approach for designing modular biomimetic
structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human …

DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp and repairs spinal cord

Y Qian, J Gong, K Lu, Y Hong, Z Zhu, J Zhang, Y Zou… - Biomaterials, 2023 - Elsevier
Dental pulp regeneration is ideal for irreversible pulp or periapical lesions, and in situ stem
cell therapy is one of the most effective therapies for pulp regeneration. In this study, we …

Design of spherically structured 3D in vitro tumor models-Advances and prospects

LP Ferreira, VM Gaspar, JF Mano - Acta biomaterialia, 2018 - Elsevier
Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

Designing microgels for cell culture and controlled assembly of tissue microenvironments

AS Caldwell, BA Aguado… - Advanced functional …, 2020 - Wiley Online Library
Micrometer‐sized hydrogels, termed microgels, are emerging as multifunctional platforms
that can recapitulate tissue heterogeneity in engineered cell microenvironments. The …

A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles

KB Gomes, B D'Souza, S Vijayanand, I Menon… - International Journal of …, 2022 - Elsevier
Effective vaccines delivered via painless methods would revolutionize the way people
approach vaccinations. This study focused on the development of fast-dissolving …

Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application

S Wen, X Zheng, W Yin, Y Liu, R Wang, Y Zhao… - Stem Cell Research & …, 2024 - Springer
Periodontitis, a globally prevalent chronic inflammatory disease is characterized by the
progressive degradation of tooth-supporting structures, particularly the periodontal ligament …

Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids

LP Ferreira, VM Gaspar, JF Mano - Biomaterials, 2018 - Elsevier
Abstract 3D multicellular tumor spheroids (3D-MCTS) that closely mimic in vitro the complex
lung tumor microenvironment (TME) are highly desirable for screening innovative anti …