IGF-binding protein 2–oncogene or tumor suppressor?

A Pickard, DJ McCance - Frontiers in endocrinology, 2015 - frontiersin.org
The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In
general, IGFBP2 is considered to be oncogenic and its expression is often observed to be …

Potential functions of IGFBP-2 for ovarian folliculogenesis and steroidogenesis

M Spitschak, A Hoeflich - Frontiers in endocrinology, 2018 - frontiersin.org
Ovarian follicles, as transient structural and functional complexes with the oocyte and the
associated cells, determine the female reproductive cycle and thus fertility. Ovarian function …

Similar dietary regulation of IGF-1-and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes

R Schüler, M Markova, MA Osterhoff, A Arafat… - European Journal of …, 2021 - Springer
Increased animal but not plant protein intake has been associated with increased mortality
in epidemiological studies in humans and with reduced lifespan in animal species. Protein …

Early-life exposure to 17β-estradiol and 4-nonylphenol impacts the growth hormone/insulin-like growth-factor system and estrogen receptors in Mozambique tilapia …

FT Celino-Brady, CK Petro-Sakuma, JP Breves… - Aquatic Toxicology, 2019 - Elsevier
It is widely recognized that endocrine disrupting chemicals (EDCs) released into the
environment through anthropogenic activities can have short-term impacts on physiological …

[HTML][HTML] Antepartal insulin-like growth factor 1 and insulin-like growth factor binding protein 2 concentrations are indicative of ketosis in dairy cows

M Piechotta, W Mysegades, U Ligges, J Lilienthal… - Journal of dairy …, 2015 - Elsevier
A study involving a small number of cows found that the concentrations of insulin-like growth
hormone 1 (IGF1) may be a useful predictor of metabolic disease. Further, IGF1 may provide …

[HTML][HTML] Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species

E Wirthgen, C Höflich, M Spitschak, C Helmer… - Growth Hormone & IGF …, 2016 - Elsevier
The insulin-like growth factor binding proteins (IGFBPs) are determinants of local IGF-effects
and thus have an impact on growth and metabolism in vertebrate species. In farm animals …

[HTML][HTML] Characterization of a novel IGFBP-2 transcript in the ovarian granulosa cells of chicken follicles: mRNA expression, function and effect of reproductive …

L Hu, D Li, Q Wei, L Kang, Y Sun, Y Jiang - Poultry Science, 2024 - Elsevier
Insulin-like growth factor binding protein-2 (IGFBP-2), a binding protein of insulin-like growth
factor (IGF) system, regulates the activity of IGFs and also influences cellular function with …

Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity

P Mester, U Räth, S Schmid, P Amend, D Keller… - Biomedicines, 2024 - mdpi.com
Insulin-like growth factor-binding protein (IGFBP)-2 is a regulator of anabolic pathways,
which become inactivated in severe illness. Here, we measured the serum IGFBP-2 levels of …

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

L Zeng, CM Perks, JMP Holly - Growth Hormone & IGF Research, 2015 - Elsevier
IGFBP-2 is an important modulator of IGF availability and activity. It is the second most
abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours …

A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells

W Ku, Y Chang, S Wu, H Shih, Y Tzeng, H Kuo… - Phytomedicine, 2017 - Elsevier
Ethnopharmacological relevance Kaempferitrin is extracted in significantly high quantities
from the leaves of Cinnamomum osmophloeum (CO) and Bauhinia forficata, and are used …