Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Repeated mild traumatic brain injury: potential mechanisms of damage

B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

W Cai, T Yang, H Liu, L Han, K Zhang, X Hu… - Progress in …, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

White matter involvement after TBI: Clues to axon and myelin repair capacity

RC Armstrong, AJ Mierzwa, CM Marion… - Experimental …, 2016 - Elsevier
Impact-acceleration forces to the head cause traumatic brain injury (TBI) with damage in
white matter tracts comprised of long axons traversing the brain. White matter injury after TBI …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

The controlled cortical impact model: applications, considerations for researchers, and future directions

ND Osier, CE Dixon - Frontiers in neurology, 2016 - frontiersin.org
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …

Astrocytes in functional recovery following central nervous system injuries

QM Alhadidi, GA Bahader, O Arvola… - The Journal of …, 2024 - Wiley Online Library
Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

Components of myelin damage and repair in the progression of white matter pathology after mild traumatic brain injury

AJ Mierzwa, CM Marion, GM Sullivan… - … of Neuropathology & …, 2015 - academic.oup.com
White matter tracts are highly vulnerable to damage from impact-acceleration forces of
traumatic brain injury (TBI). Mild TBI is characterized by a low density of traumatic axonal …

Glucocorticoids, genes and brain function

GR Juszczak, AM Stankiewicz - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …