Background Poor wound healing is a significant complication of diabetes, which is
commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the
leading causes of death. Diabetes is a genetic disease; however, the environment plays …

Type 1 diabetes (T1D) is an irreversible degenerative disease with severe complications
such as heart disease, nephropathy, neuropathy, and retinopathy. Although exogenous …

Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction
between genetic alterations and environmental factors. More than 60 susceptible genes or …

DNA methyltransferase (DNMT) inhibitors regulate target gene expression through
epigenetic modifications and these compounds have primarily been studied for cancer …

The transcription factor PDX1 is a master regulator essential for proper development of the
pancreas, duodenum and antrum. Furthermore, it is an indispensable reprogramming factor …

Pancreas development is controlled by a complex interaction of signaling pathways and
transcription factor networks that determine pancreatic specification and differentiation of …

Cell replacement therapy is a promising method to restore pancreatic β cell function and
cure diabetes. Distantly related cells (fibroblasts, keratinocytes, and muscle cells) and …

Abstract Purpose of the Review Here, we review recent findings in the field of generating
insulin-producing cells by pancreatic transcription factor (pTF)-induced liver …