In situ detection of neural progenitor cells including stem-like cells is essential for studying
the basic mechanisms of the generation of cellular diversity in the CNS, upon which …

Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the
cerebral ventricles of all adult animals, including humans. In addition, distinct populations of …

The subcortical white matter of the adult human brain harbors a pool of glial progenitor cells.
These cells can be isolated by fluorescence-activated cell sorting (FACS) after either …

Neural progenitor cells, including neural stem cells, are a potential expandable source of
graft material for transplantation aimed at repairing the damaged CNS. Here we present the …

Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current
understanding of the metabolic interactions between neurons and glia is based on studies …

Recentin vitrostudies have shown that the periventricular subependymal zone (SEZ) of the
rodent brain is capable ofde novogeneration of neurons and glia. There is less information …

In an attempt to better understand and control the processes that regulate stem cell fate, we
have set out to identify small molecules that induce neuronal differentiation in embryonic …

Over the past year, evidence has accrued that adult CNS stem cells are a widespread
progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain …

Although stem cells hold considerable promise for the treatment of numerous diseases
including cardiovascular disease, neurodegenerative disease, musculoskeletal disease …

We generated transgenic mice carrying enhanced green fluorescent protein (EGFP) under
the control of the nestin second-intronic enhancer (E/nestin: EGFP). Flow cytometry followed …