Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates
and peptide-modified drug delivery systems provide new opportunities to avoid macrophage …

The safety issues like immunogenicity and unacceptable cancer risk of viral vectors for
DNA/mRNA vaccine delivery necessitate the development of non-viral vectors with no …

Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Drug delivery to avascular, negatively charged tissues like cartilage remains a challenge.
The constant turnover of synovial fluid results in short residence time of administered drugs …

Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the
immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a …

Triple negative breast cancers are an aggressive subtype of breast cancer, characterized by
the lack of estrogen receptor, progesterone receptor and Her2 expression. Triple negative …

Trp is unique among the amino acids since it is involved in many different types of
noncovalent interactions such as electrostatic and hydrophobic ones, but also in π-π, π …

Cancer is the second leading cause of death in the world and its treatment is extremely
challenging, mainly due to its complexity. Cell-Penetrating Peptides (CPPs) are peptides …