Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

Cardiac macrophages represent a functionally diverse population of cells involved in
cardiac homeostasis, repair, and remodeling. With recent advancements in single-cell …

There is great interest in identifying signaling pathways that promote cardiac repair after
myocardial infarction (MI). Prior studies suggest a beneficial role for IL-13 signaling in …

The pathogenesis of allograft (dys) function has been increasingly studied using 'omics'-
based technologies, but the focus on individual organs has created knowledge gaps that …

Aims Understanding the cellular mechanisms underlying early allograft rejection is crucial
for the development of effective immunosuppressant strategies. This study aims to …

Solid organ transplant represents a potentially lifesaving procedure for patients suffering
from end-stage heart, lung, liver, and kidney failure. However, rejection remains a significant …

Cardiac allograft vasculopathy (CAV) is a leading cause of late graft failure and mortality
after heart transplantation (HT). Sharing some features with atherosclerosis, CAV results in …

Transplantation is a life-saving therapy for patients with end-stage organ disease.
Successful outcomes after transplantation require mitigation of the post-transplant …

Immunoregulation and indoleamine 2, 3-dioxygenase 1 (IDO1) play pivotal roles in the
rejection of allogeneic organ transplantation. This study aims to elucidate the immune …

Solid organ transplantation mobilizes myeloid cells, including monocytes and macrophages,
which are central protagonists of allograft rejection. However, myeloid cells can also be …