Glycoproteomics
Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …
proteins and is a crucial protein modification in health and disease. The aim of …
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition
Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …
[HTML][HTML] Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approach
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the
ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency of …
ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency of …
Glycan-specific molecularly imprinted polymers towards cancer diagnostics: merits, applications, and future perspectives
Aberrant glycans are a hallmark of cancer states. Notably, emerging evidence has
demonstrated that the diagnosis of cancers with tumour-specific glycan patterns holds great …
demonstrated that the diagnosis of cancers with tumour-specific glycan patterns holds great …
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications
Glycans cover the surfaces of all mammalian cells through a process called glycosylation.
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …
Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory …
The challenges of glycan recognition with natural and artificial receptors
S Tommasone, F Allabush, YK Tagger… - Chemical Society …, 2019 - pubs.rsc.org
Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …
modulators of numerous physiological and pathological processes. Thus, many …
The effect of hypoxia and hypoxia-associated pathways in the regulation of antitumor response: friends or foes?
R Abou Khouzam, RF Zaarour… - Frontiers in …, 2022 - frontiersin.org
Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …
Tolerogenic immunotherapy: targeting DC surface receptors to induce antigen-specific tolerance
C Castenmiller, BC Keumatio-Doungtsop… - Frontiers in …, 2021 - frontiersin.org
Dendritic cells (DCs) are well-established as major players in the regulation of immune
responses. They either induce inflammatory or tolerogenic responses, depending on the DC …
responses. They either induce inflammatory or tolerogenic responses, depending on the DC …