[HTML][HTML] Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

J Mondal, S Pillarisetti, V Junnuthula, M Saha… - Journal of Controlled …, 2023 - Elsevier
Exosomes are endosome-derived nanovesicles involved in cellular communication. They
are natural nanocarriers secreted by various cells, making them suitable candidates for …

Non-viral vectors for RNA delivery

Y Yan, XY Liu, A Lu, XY Wang, LX Jiang… - Journal of Controlled …, 2022 - Elsevier
RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Exosomes: Therapy delivery tools and biomarkers of diseases

L Barile, G Vassalli - Pharmacology & therapeutics, 2017 - Elsevier
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …

[HTML][HTML] Designer exosomes: a new platform for biotechnology therapeutics

D Jafari, S Shajari, R Jafari, N Mardi, H Gomari, F Ganji… - BioDrugs, 2020 - Springer
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

PEM de Castilla, L Tong, C Huang, AM Sofias… - Advanced drug delivery …, 2021 - Elsevier
During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

[HTML][HTML] Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

C Gong, J Tian, Z Wang, Y Gao, X Wu, X Ding… - Journal of …, 2019 - Springer
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …

[HTML][HTML] The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

P Hong, H Yang, Y Wu, K Li, Z Tang - Stem cell research & therapy, 2019 - Springer
Exosomes are extracellular membranous nanovesicles that mediate local and systemic
intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into …