Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

AO Elzoghby, MA Abdelmoneem, IA Hassanin… - Biomaterials, 2020 - Elsevier
Recent progress in protein-based nanomedicine, inspired by the success of Abraxane®
albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of …

Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action

A Cutone, L Rosa, G Ianiro, MS Lepanto… - Biomolecules, 2020 - mdpi.com
Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

Iron in the tumor microenvironment—connecting the dots

C Pfeifhofer-Obermair, P Tymoszuk, V Petzer… - Frontiers in …, 2018 - frontiersin.org
Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: current knowledge

MF Ashraf, D Zubair, MN Bashir, M Alagawany… - … Trace Element Research, 2024 - Springer
Lactoferrin is a natural cationic iron-binding glycoprotein of the transferrin family found in
bovine milk and other exocrine secretions, including lacrimal fluid, saliva, and bile …

Time to kill and time to heal: the multifaceted role of lactoferrin and lactoferricin in host defense

A Ohradanova-Repic, R Praženicová, L Gebetsberger… - Pharmaceutics, 2023 - mdpi.com
Lactoferrin is an iron-binding glycoprotein present in most human exocrine fluids,
particularly breast milk. Lactoferrin is also released from neutrophil granules, and its …

Beyond formulation: contributions of nanotechnology for translation of anticancer natural products into new drugs

RA Miguel, AS Hirata, PC Jimenez, LB Lopes… - Pharmaceutics, 2022 - mdpi.com
Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two
examples of natural-product-derived drugs employed as first-line treatment of various cancer …

Augmenting apoptosis-mediated anticancer activity of lactoperoxidase and lactoferrin by nanocombination with copper and iron hybrid nanometals

EM El-Fakharany, MM Abu-Serie, NH Habashy… - Scientific reports, 2022 - nature.com
There is an urgent need in the medicinal fields to discover biocompatible nanoformulations
with low cytotoxicity, which provide new strategies for promising therapies for several types …

Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine

MM Agwa, S Sabra - International Journal of Biological Macromolecules, 2021 - Elsevier
A successful drug delivery to a specific site relies on two essential factors including; efficient
entrapment of the drug within the carrier and successful delivery of drug-loaded nanocarrier …

Unlocking the potential of milk whey protein components in colorectal cancer prevention and therapy

J Xiao, J Ma, MZ Khan, GM Alugongo… - Critical Reviews in …, 2024 - Taylor & Francis
Extensive research from large prospective cohort studies and meta-analytical investigations
over recent decades have consistently indicated that dairy foods have protective effects …

A thermo-responsive chemically crosslinked long-term-release chitosan hydrogel system increases the efficiency of synergy chemo-immunotherapy in treating brain …

SH Chuang, KJ Chen, YT Cheng, YS Chen… - International Journal of …, 2024 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive and common brain tumor. The blood-brain
barrier prevents several treatments from reaching the tumor. This study proposes a Chemo …