Cell-based therapies for Parkinson disease—past insights and future potential
Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide
dopaminergic innervation to the striatum. This discovery led to the successful instigation of …
dopaminergic innervation to the striatum. This discovery led to the successful instigation of …
How to make a midbrain dopaminergic neuron
Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …
during recent years. This is due in part to a growing interest in regenerative medicine and …
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation
Generation of precisely patterned neural cells from human pluripotent stem cells (hPSCs) is
instrumental in developing disease models and stem cell therapies. Here, we provide a …
instrumental in developing disease models and stem cell therapies. Here, we provide a …
Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
Long non‐coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the
human genome, which have been proposed to be key regulators of biological processes …
human genome, which have been proposed to be key regulators of biological processes …
Embryonic stem cell differentiation: emergence of a new era in biology and medicine
G Keller - Genes & development, 2005 - genesdev.cshlp.org
The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …
advance in biology and experimental medicine, as it enabled the routine manipulation of the …
Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells
SH Yuan, J Martin, J Elia, J Flippin, RI Paramban… - PloS one, 2011 - journals.plos.org
Background Neural induction of human pluripotent stem cells often yields heterogeneous
cell populations that can hamper quantitative and comparative analyses. There is a need for …
cell populations that can hamper quantitative and comparative analyses. There is a need for …
Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells
H Kurosawa - Journal of bioscience and bioengineering, 2007 - Elsevier
When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …
spontaneously differentiate and form three-dimensional multicellular aggregates called …
Conductive hydrogels based on agarose/alginate/chitosan for neural disorder therapy
Electroactive scaffolds derived from carbohydrate hydrogels were synthesized, resulting in a
large shift in the conductivity of chitosan (CS) from 10− 6 S/cm to about 10-3 S/cm, assigned …
large shift in the conductivity of chitosan (CS) from 10− 6 S/cm to about 10-3 S/cm, assigned …
Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions
A Swistowski, J Peng, Q Liu, P Mali, MS Rao… - Stem …, 2010 - academic.oup.com
Human induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells represent a
promising unlimited cell source for generating patient-specific cells for biomedical research …
promising unlimited cell source for generating patient-specific cells for biomedical research …
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma …
A Brederlau, AS Correia, SV Anisimov, M Elmi… - Stem …, 2006 - academic.oup.com
Human embryonic stem cells (hESCs) have been proposed as a source of dopamine (DA)
neurons for transplantation in Parkinson's disease (PD). We have investigated the effect of in …
neurons for transplantation in Parkinson's disease (PD). We have investigated the effect of in …