Myc is a transcription factor driving growth and proliferation of cells and involved in the
majority of human tumors. Despite a huge body of literature on this critical oncogene, our …

The Endosomal Sorting Complex Required for Transport (ESCRT) machinery consists of
multiple protein complexes that coordinate vesicle budding away from the host cytosol …

Toxoplasma gondii is a master manipulator capable of effectively siphoning the resources
from the host cell for its intracellular subsistence. However, the molecular underpinnings of …

Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.
Studies of motif-mediated interactions therefore provide insight into virus-host …

The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in
primates. However, there are no regulatorily approved drugs against the Ebola virus disease …

The endosomal sorting complex required for transport (ESCRT) machinery plays a
significant role in the spread of human viruses. However, our understanding of how the host …

Most viruses have small genomes that encode proteins needed to perform essential
enzymatic functions. Across virus families, primary enzyme functions are under functional …

The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein
sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins …

Marburg virus (MARV) VP40 protein (mVP40) directs egress and spread of MARV, in part, by
recruiting specific host WW domain-containing proteins via its conserved PPxY late (L) …

The recognition of PPxY viral Late domains by the third WW domain of the human HECT-E3
ubiquitin ligase NEDD4 (NEDD4-WW3) is essential for the budding of many viruses …