Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

End-stage organ failure is a key challenge for the medical community because of the ageing
population and the severe shortage of suitable donor organs available. Equally, injuries to …

Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM)
are commonly used for the repair and remodeling of injured tissue. The clinical outcomes …

Summary Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give
rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells …

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

Approximately 285 million people worldwide suffer from diabetes, with insulin
supplementation as the most common treatment measure. Regenerative medicine …

Background Organ engineering is a theoretical alternative to allotransplantation for end-
stage organ failure. Whole-organ scaffolds can be created by detergent perfusion via the …

Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate
into other cell types is a promising avenue in regenerative medicine. Stem cell niche not …

Background The only definitive treatment for end-stage organ failure is orthotopic
transplantation. Lung extracellular matrix (LECM) holds great potential as a scaffold for lung …

Decellularized tissues have been successfully used in a variety of tissue engineering/
regenerative medicine applications, and more recently decellularized organs have been …