Our understanding of the fundamental regulatory roles that tyrosine phosphatases play
within cells has advanced significantly in the last two decades. Out-dated ideas that tyrosine …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

There is an increasing number of neurologic disorders found to be associated with loss
and/or dysfunction of the CNS myelin sheath, ranging from the classic demyelinating …

After inflammation-induced demyelination, such as in the disease multiple sclerosis,
endogenous remyelination often fails. However, in animal models of demyelination induced …

Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult
neurons and regulates neural regeneration. We recently discovered that PTPσ is also …

Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid
(SAHA), to a culture broth of the endophytic fungus Phoma sp. nov. LG0217 isolated from …

Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development
and progression of human cancers. Historically, however, PTPs have not been viewed as …

The drug discovery landscape is littered with promising therapeutic targets that have been
abandoned because of insufficient validation, historical screening failures, and inferior …

Background The protein tyrosine phosphatases PTP1B and SHP2 are promising drug
targets in treatment design for breast cancer. Searching for specific inhibitors of their activity …

The use of computational tools for virtual screening provides a cost-efficient approach to
select starting points for drug development. We have developed VSpipe, a user-friendly …