Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the
methylation of lysine 27 on histone H3 (H3K27me). This histone modification is a feature of …

It is generally considered that Polycomb Repressive Complex (PRC) 2 deposits the histone
mark H3K27me3 on silent protein-coding genes, while transposable elements are …

Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …

Epigenetic alteration has been implicated in aging. However, the mechanism by which
epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA
repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are …

Comparative genomics has recently provided unprecedented insights into the biology and
evolution of the fungal lineage. In the postgenomics era, a major research interest focuses …

Chromosome and genome stability are important for normal cell function as instability often
correlates with disease and dysfunction of DNA repair mechanisms. Many organisms …

Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved
multi-subunit complexes that repress gene transcription by introducing trimethylation of …