The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires
recruitment of mural cells, generation of an extracellular matrix and specialization of the …

The adventitial layer surrounding the blood vessels has long been exclusively considered a
supporting tissue the main function of which is to provide adequate nourishment to the …

Electrospinning has recently emerged as a leading technique for generating biomimetic
scaffolds made of synthetic and natural polymers for tissue engineering applications. In this …

Electrospinning using natural proteins or synthetic polymers is a promising technique for the
fabrication of fibrous scaffolds for various tissue engineering applications. However, one …

Abstract Sphingosine-1-phosphate (S1P) stimulates signaling pathways via G-protein-
coupled receptors and triggers diverse cellular processes, including growth, survival, and …

Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

Pericytes have been difficult cells to study because they do not maintain their characteristic
phenotype in vitro, and they begin to express fibroblast markers after only a few days in …

The ability to create thick tissues is a major tissue engineering challenge, requiring the
development of a suitable vascular supply. Current trends are seeing the utilization of cells …

Clinical protocols utilize bone marrow to seed synthetic and decellularized allogeneic bone
grafts for enhancement of scaffold remodeling and fusion. Marrow-derived cytokines induce …

Mesenchymal stem cells (MSC) are adult stem cells with capacity for self-renewal and multi-
lineage differentiation. Initially described in bone marrow, MSC are also present in other …