Exosomal circRNAs in cancer: implications for therapy resistance and biomarkers

Z Lin, Y Ji, J Zhou, G Li, Y Wu, W Liu, Z Li, T Liu - Cancer Letters, 2023 - Elsevier
Despite the advances in cancer treatment in recent years, the development of resistance to
cancer therapy remains the biggest hurdle towards curative cancer treatments. Therefore …

[HTML][HTML] Physiological and pathological functions of circular RNAs in the nervous system

M Zhou, S Li, C Huang - Neural Regeneration Research, 2024 - journals.lww.com
Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are
expressed during the development of specific cells and tissues. CircRNAs play crucial roles …

Roles of circular RNAs in osteogenic/osteoclastogenic differentiation

T Wang, C Zhang, L Xu, X Li - Biofactors, 2024 - Wiley Online Library
The process of bone remodeling occurs and is regulated through interactions between
osteoclasts, which resorb bone, and osteoblasts, which generate bone tissue. When the …

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Z Wu, X Yu, S Zhang, Y He, W Guo - Frontiers in Immunology, 2022 - frontiersin.org
Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been
reported to be expressed in eukaryotic cells and have a variety of biological functions in the …

Computational approaches for circRNA-disease association prediction: a review

M Niu, Y Chen, C Wang, Q Zou, L Xu - Frontiers of Computer Science, 2025 - Springer
Circular RNA (circRNA) is a covalently closed RNA molecule formed by back splicing. The
role of circRNAs in posttranscriptional gene regulation provides new insights into several …

circRNA: a promising all-around star in the future

H Li - Epigenomics, 2023 - Taylor & Francis
circRNA is a type of RNA molecule with a circular structure. From initially thinking it was
useless to now discovering that it has important and complex functions, the importance of …

A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli

SA Giusti, NS Pino, C Pannunzio, MB Ogando… - Science …, 2024 - science.org
Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of
thousands of circular transcripts, the biological significance of most of them remains …

Circular RNAs in hepatocellular carcinoma: biogenesis, function, and pathology

G Rao, X Peng, Y Tian, X Fu, Y Zhang - Frontiers in Genetics, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide. Both genetic and environmental factors through a multitude of underlying …

Biological functions, mechanisms, and clinical significance of circular RNA in colorectal cancer

G Fang, D Xu, T Zhang, G Wang, L Qiu, X Gao… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide due to the
lack of effective diagnosis and prognosis biomarkers and therapeutic targets, resulting in …

Development and disease-specific regulation of RNA splicing in cardiovascular system

J Jiang, H Wu, Y Ji, K Han, JM Tang, S Hu… - Frontiers in Cell and …, 2024 - frontiersin.org
Alternative splicing is a complex gene regulatory process that distinguishes itself from
canonical splicing by rearranging the introns and exons of an immature pre-mRNA …