The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …

Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …

Objective: To determine whether anemia is associated with incident dementia in older
adults. Methods: We studied 2,552 older adults (mean age 76.1 years; 38.9% black; 51.8 …

Background Alzheimer's disease (AD) and diabetes mellitus (DM) often coexist in patients
because having one of these conditions increases risk for the other. These two diseases …

Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation
and progression of varied disorders throughout the body. It therefore becomes imperative to …

Erythropoietin (EPO) is a cytokine known to have effective cytoprotective action in the brain,
particularly in ischemic, traumatic, inflammatory, and neurodegenerative conditions. We …

Alzheimer's disease (AD) is the major form of age-related dementia and is characterized by
progressive cognitive impairment, the accumulation of extracellular amyloid β-peptide (Aβ) …

Today, it is widely accepted that ADDLs, soluble oligomeric assemblies of the amyloid β
peptide, play a prominent role in triggering the cognitive deficits and neurodegeneration that …

New treatment strategies with erythropoietin (EPO) offer exciting opportunities to prevent the
onset and progression of neurodegenerative disorders that currently lack effective therapy …

Oxidative stress impacts multiple systems of the body and can lead to some of the most
devastating consequences in the nervous system especially during aging. Both acute and …