Lipopolysaccharide is a virulence factor of gram‐negative bacteria with a crucial importance
to the bacterial surface integrity. From the host's perspective, lipopolysaccharide plays a role …

In recent years, much new data on intestinal alkaline phosphatase (IAP) have been
published, and major breakthroughs have been disclosed. The aim of the present review is …

OBJECTIVE Dysbiosis of the gut microbiota has been linked to disease pathogenesis in type
1 diabetes, yet the functional consequences to the host of this dysbiosis are unknown. We …

An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the
immune system and may result in chronic inflammation. The epithelial cells of the intestinal …

Diabetic kidney disease (DKD) is a devastating condition associated with increased
morbidity and premature mortality. The etiology of DKD is still largely unknown. However …

The intestinal barrier is critical for maintaining intestinal homeostasis, and its dysfunction is
associated with various diseases. Recent findings have revealed the multifunctional role of …

Background: Improved understanding of the pathophysiology causing diabetic kidney
disease (DKD) is imperative. The aim of this study was to uncover associations between …

Rationale: Intestinal alkaline phosphatase (IAP) is secreted by enterocytes and is present on
the apical surface. It not only detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the …

Abstracts Background The development of gut-liver axis metabolic immune crosstalk is
intimately associated with intestinal barrier disorder, intestinal SCFAs-Th17/Treg …

Abstract P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are involved in
intestinal barrier. Short-chain fatty acids (SCFAs) play important roles in maintaining …