Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

Studies on the increasing number of transporters found in the placental barrier are gaining
momentum, because of their tissue‐specific expression, significance in physiology and …

ABSTRACT Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein
(BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and …

An adverse early-life environment is associated with long-term disease consequences.
Adversity early in life is hypothesized to elicit developmental adaptations that serve to …

Obesity and gestational diabetes mellitus (GDM) are becoming more common among
pregnant women worldwide and are individually associated with a number of placenta …

Bisphenol A (BPA), an estrogen-like chemical, leaches from consumer products potentially
causing human exposure. To examine the effects of BPA exposure during pregnancy, we …

Detailed understanding of the mechanisms employed in transfer of drugs across the
placenta is essential for optimization of pharmacotherapy during pregnancy. Disclosure of …

The multidrug resistance phosphoglycoprotein ATP-binding cassette subfamily B (ABCB1)
actively extrudes a range of structurally and functionally diverse xenobiotics as well as …