Both oxidative stress and inflammation are enhanced in chronic heart failure. Dysfunction of
cardiac mitochondria is a hallmark of heart failure and a leading cause of oxidative stress …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged
cardiac metabolism and abnormal redox state during cardiac diseases foment …

Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an
implantable cardioverter defibrillator have limitations, and it is important to search for new …

Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the
incessant electrical activity and contractile action of cardiac muscle. Emerging evidence …

Background—Previously, we showed that a mouse model (ACE8/8) of cardiac renin–
angiotensin system activation has a high rate of spontaneous ventricular tachycardia and …

The voltage-gated Na channel isoform 1.5 (NaV1. 5) is the pore forming α-subunit of the
voltage-gated cardiac Na channel, which is responsible for the initiation and propagation of …

Objectives: The aim of this study was to test whether c-Src tyrosine kinase mediates
connexin-43 (Cx43) reduction and sudden cardiac death in a transgenic mouse model of …

Atrial fibrillation (AF) is the most common arrhythmia that requires medical attention, and its
incidence is increasing. Current ion channel blockade therapies and catheter ablation have …

Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease, associated with
ventricular arrhythmias, fibrofatty replacement of the myocardial mass and an increased risk …