Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

Humans have exceptionally long lifespans compared with other mammals. However, our
longevity evolved when our ancestors had two copies of the apolipoprotein E (APOE) ɛ4 …

Disease epidemiology during ageing shows a transition from cancer to degenerative chronic
disorders as dominant contributors to mortality in the old. Nevertheless, it has remained …

Abnormal cognitive ageing, including dementia, poses serious challenges to health and
social systems in ageing populations. As such, characterizing factors associated with …

In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

Background The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental
outcomes in affluent populations including atherosclerotic disease, Alzheimer's disease, and …

Complex diseases are major contributors to human mortality in old age. Paradoxically, many
genetic variants that have been associated with increased risks of such diseases are found …

Alzheimer's disease (AD) risk increases exponentially with age and is associated with
multiple molecular hallmarks of aging, one of which is epigenetic alterations. Epigenetic age …

Background The human apolipoprotein E (APOE) gene is polymorphic, with three primary
alleles (E2, E3, E4) that differ at two key non-synonymous sites. These alleles are …

Personalized medicine uses various individual characteristics to guide medical decisions.
Apolipoprotein (ApoE), the most studied polymorphism in humans, has been associated with …