Redundant and regulatory roles for Toll-like receptors in Leishmania infection

P Chauhan, D Shukla… - Clinical & …, 2017 - academic.oup.com
Toll-like receptors (TLRs) are germline-encoded, non-clonal innate immune receptors,
which are often the first receptors to recognize the molecular patterns on pathogens …

Innate immunomodulation to trypanosomatid parasite infections

ALA Dos-Santos, LF Carvalho-Kelly, CF Dick… - Experimental …, 2016 - Elsevier
The recognition of invading pathogens by the innate immune system is essential for host
protection against human parasites and the initiation of an effective adaptive immune …

TLR specific immune responses against helminth infections

S Rajasekaran, R Anuradha… - Journal of Parasitology …, 2017 - Wiley Online Library
Despite marked improvement in the quality of lives across the globe, more than 2 million
individuals in socioeconomically disadvantaged environments remain infected by helminth …

Immunoregulatory function of SP-A

S Dong, H Pang, F Li, M Hua, M Liang, C Song - Molecular Immunology, 2024 - Elsevier
Abstract Surfactant protein A (SP-A), a natural immune molecule, plays an important role in
lung health. SP-A recognizes and binds microbial surface glycogroups through the C-type …

Leishmania Promastigotes Enhance Neutrophil Recruitment through the Production of CXCL8 by Endothelial Cells

S D'Alessandro, S Parapini, Y Corbett, R Frigerio… - Pathogens, 2021 - mdpi.com
Endothelial cells represent one of the first cell types encountered by Leishmania
promastigotes when inoculated into the skin of the human hosts by the bite of phlebotomine …

[HTML][HTML] Neutrophil elastase promotes Leishmania donovani infection via interferon-β

BT Dias, KL Dias-Teixeira, JP Godinho… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Visceral leishmaniasis is a deadly illness caused by Leishmania donovani that provokes
liver and spleen inflammation and tissue destruction. In cutaneous leishmaniasis, the protein …

Curative efficacy of purified serine protease inhibitor PTF3 from potato tuber in experimental visceral leishmaniasis

D Paik, PK Pramanik, T Chakraborti - International Immunopharmacology, 2020 - Elsevier
To overcome the drug toxicity and frequent resistance of parasites against the conventional
drugs for the healing of human visceral leishmaniasis, innovative plant derived …

Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids

S Pradhan, D Manna, S Karmakar, MK Singh… - Heliyon, 2022 - cell.com
Immunotherapeutic strategies against visceral leishmaniasis (VL) are pertinent because of
the emergence of resistance against existing chemotherapy, coupled with their toxicity and …

RNA‐Sequencing of ovine PBMC after exposure to Haemonchus contortus larval antigen

JR Jacobs, D Middleton, SP Greiner… - Parasite …, 2020 - Wiley Online Library
Mechanisms of immune activation in effector cells during Haemonchus contortus infection in
sheep are currently unknown. Microarray experiments have been performed on tissues of H …

Recent trends in Leishmania research: A therapeutic perspective

JJ Jawed, S Majumdar - Journal of Infectiology and …, 2018 - infectiologyjournal.com
Leishmaniasis is a spectrum of disease caused by the infection of protozoan parasite
Leishmania mainly affecting the antigen presenting cell of the host. The disease is although …