Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …

Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

Inherited retinal dystrophies and late-stage age-related macular degeneration, for which
treatments remain limited, are among the most prevalent causes of legal blindness. Retinal …

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Animal studies are now showing the exciting potential to achieve significant functional
recovery following central nervous system (CNS) injury by manipulating both the inefficient …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Adult brain plasticity, although possible, remains more restricted in scope than during
development. Here, we address conditions under which circuit rewiring may be facilitated in …

Recent studies have deepened our understanding of multiple mechanisms by which
extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and …