Phosphatidylinositol-3-phosphate (PtdIns (3) P) is essential for cell survival, and its
intracellular synthesis is spatially and temporally regulated. It has major roles in two …

Branched-chain amino acids (BCAA: leucine, isoleucine, and valine) are three of the nine
indispensable amino acids, and are frequently consumed as a dietary supplement by …

The activation of the mechanistic target of rapamycin complex 1 (mTORC1), a master
regulator of protein synthesis, by anabolic stimuli (such as muscle contraction or essential …

Skeletal muscle anabolism is driven by numerous stimuli such as growth factors, nutrients
(ie, amino acids, glucose), and mechanical stress. These stimuli are integrated by the …

The influx of essential amino acids into skeletal muscle is primarily mediated by the large
neutral amino acid transporter 1 (LAT1), which is dependent on the glutamine gradient …

We recently demonstrated that acute oral ketone monoester intake induces a stimulation of
postprandial myofibrillar protein synthesis rates comparable to that elicited following the …

Following anabolic stimuli (mechanical loading and/or amino acid provision), the
mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of protein …

In its simplest terms, nutrition provides the basis of all physical performance. What we eat
provides the substrates from both intramuscular (ie glycogen and intramuscular triglyceride …

The present study used immunofluorescence methods to investigate the effect of dietary
leucine on the postprandial intracellular regulation of mTORC1 trafficking and a readout of …

Following anabolic stimuli (eg mechanical loading and/or amino acid provision) the
mechanistic target of rapamycin complex 1 (mTORC1), a master regulator of protein …