Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

The human cerebral vasculature originates in the fourth week of gestation and continues to
expand and diversify well into the first few years of postnatal life. A key feature of this growth …

Microgravity induces three-dimensional (3D) growth in numerous cell types. Despite
substantial efforts to clarify the underlying mechanisms for spheroid formation, the precise …

In humans, specific patterns of killer immunoglobulin-like receptors (KIRs) expressed by
uterine natural killer (uNK) cells are linked through HLA-C with pregnancy complications …

Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes
angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF …

Hypoxia can induce functional and structural vascular remodeling by changing the
expression of trophic factors to promote homeostasis. While most experimental approaches …

Objectives: The therapeutic use of the vascular endothelial growth factor (VEGF) antagonist
sunitinib is limited by sunitinib-induced hypertension. The hypotheses were tested that …

Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth
muscle, although hypoxia produces only transient increases in VEGF that return to normoxic …

Fetal hypoxia triggers compensatory angiogenesis and remodeling through mechanisms not
fully elucidated. In response to hypoxia, hypoxia-inducible factor drives expression of …

Rapid postnatal growth and differentiation of fetal arterial smooth muscle is coordinated by a
cacophony of growth factors, one of the most important of which is vascular endothelial …