The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …

Covering: 1965–2014 Fungi (Ascomycota and Basidiomycota) are prolific producers of
structurally diverse terpenoid compounds. Classes of terpenoids identified in fungi include …

We present crystallographic and functional data of selina‐4 (15), 7 (11)‐diene synthase
(SdS) from Streptomyces pristinaespiralis in its open and closed (ligand‐bound) …

Terpene synthases (TSs) catalyse the most complex cyclization cascades in nature, with
generation and taming of reactive carbocations. Although deprotonation–reprotonation …

Engineering sesquiterpene synthases to form predefined alternative products is a major
challenge due to their diversity in cyclization mechanisms and our limited understanding of …

Terpenes constitute the largest and structurally most diverse natural product family. Most
terpenoids exhibit a stereochemically complex macrocyclic core, which is generated by C–C …

Terpenes are an important and diverse class of secondary metabolites widely produced by
fungi. Volatile compound screening of a fungal endophyte collection revealed a number of …

Terpenoids form the largest and stereochemically most diverse class of natural products,
and there is considerable interest in producing these by biocatalysis with whole cells or …

Terpenoids are an intriguing class of natural products with diverse structures and biological
activities whose complexity stems in large part from terpene synthases (TPSs). These …