Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …

Allergic bronchopulmonary aspergillosis (ABPA) is a Th2 hypersensitivity lung disease in
response to Aspergillus fumigatus that affects asthmatic and cystic fibrosis (CF) patients …

Rationale: Severe asthma (SA) is a heterogeneous disease with multiple molecular
mechanisms. Gene expression studies of bronchial epithelial cells in individuals with …

Asthma and chronic obstructive pulmonary disease (COPD) show similarities and
substantial differences. The Dutch hypothesis stipulated that asthma and COPD have …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

BACKGROUND: Genome-wide association studies have identified determinants of chronic
obstructive pulmonary disease, asthma, and lung function level; however, none have …

Asthma is a common disorder of the airways characterized by airway inflammation and by
decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling …

The interaction between the serine protease urokinase-type plasminogen activator (uPA)
and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell …