The 2021 WHO classification of tumors of the central nervous system: a summary
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS),
published in 2021, is the sixth version of the international standard for the classification of …
published in 2021, is the sixth version of the international standard for the classification of …
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
D Sturm, D Capper, F Andreiuolo, M Gessi… - Nature medicine, 2023 - nature.com
The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Major changes in 2021 world health organization classification of central nervous system tumors
The World Health Organization (WHO) published the fifth edition of the WHO Classification
of Tumors of the Central Nervous System (WHO CNS5) in 2021, as an update of the WHO …
of Tumors of the Central Nervous System (WHO CNS5) in 2021, as an update of the WHO …
2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist
The fifth edition of the World Health Organization Classification of Tumours of the Central
Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and …
Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and …
Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant
E de Billy, M Pellegrino, D Orlando, G Pericoli… - Neuro …, 2022 - academic.oup.com
Background Diffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic
pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although …
pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although …
Pediatric diffuse midline glioma H3K27-altered: A complex clinical and biological landscape behind a neatly defined tumor type
The 2021 World Health Organization Classification of Tumors of the Central Nervous
System, Fifth Edition (WHO-CNS5), has strengthened the concept of tumor grade as a …
System, Fifth Edition (WHO-CNS5), has strengthened the concept of tumor grade as a …
A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
Malignant brain tumors, known as H3K27-altered diffuse midline glioma (DMG) and H3G34-
mutant diffuse hemispheric glioma (DHG), can affect individuals of all ages and are …
mutant diffuse hemispheric glioma (DHG), can affect individuals of all ages and are …
[HTML][HTML] Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification
F Gianno, I Giovannoni, B Cafferata… - Pathologica, 2022 - ncbi.nlm.nih.gov
As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive
pathobiology underlying gliomas arising primarily in children by recognizing for the first time …
pathobiology underlying gliomas arising primarily in children by recognizing for the first time …