The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

Background & Aims Excessive consumption of ethanol is one of the most common causes of
acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that
conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the …

Current findings have provided further insight into the roles and mechanisms of zymogen
activation and inflammatory pathways in pancreatic injury. Future studies, which will be of …

Acute pancreatitis (AP) is a leading cause of hospitalization among non-malignant
gastrointestinal disorders. The mortality of severe AP can reach 30–50%, which is most …