Abstract Changes in levels of the stress-sensitive hormone cortisol from morning to evening
are referred to as diurnal cortisol slopes. Flatter diurnal cortisol slopes have been proposed …

The immune system is a complex set of physiological mechanisms whose general aim is to
defend the organism against non-self-bodies, such as pathogens (bacteria, viruses …

The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here
we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

Circadian rhythms are 24-h patterns regulating behavior, organs, and cells in living
organisms. These rhythms align biological functions with regular and predictable …

Bipolar disorder is a mental health disorder characterized by extreme shifts in mood, high
suicide rate, sleep problems, and dysfunction of psychological traits like self-esteem (feeling …

After the characterization of the central pacemaker in the suprachiasmatic nucleus, the
expression of clock genes was identified in several peripheral tissues including the immune …

In recent years, relationship between free radicals and oxidative stress with aging, cancer,
atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Background Noise in intensive care units (ICUs) has always been a problem, but noise
above the recommended range affects not only the patient but staff as well. It is clear that …