Antimicrobial peptides: challenging journey to the pharmaceutical, biomedical, and cosmeceutical use

A Mazurkiewicz-Pisarek, J Baran, T Ciach - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life
forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in …

[HTML][HTML] Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

JP Yadav, A Verma, P Pathak, AR Dwivedi… - Biomedicine & …, 2024 - Elsevier
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process,
contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation …

[HTML][HTML] Bioactive antimicrobial peptides as therapeutic agents for infected diabetic foot ulcers

J Da Silva, EC Leal, E Carvalho - Biomolecules, 2021 - mdpi.com
Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic
patients and representing a leading cause of non-traumatic amputations. Notably, the risk of …

No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection

M Răileanu, R Borlan, A Campu, L Janosi… - International Journal of …, 2023 - Elsevier
In recent years, the unprecedented rise of bacterial antibiotic resistance together with the
lack of adequate therapies have made the treatment of skin infections and chronic wounds …

Cationic arginine-rich peptides (CARPs): a novel class of neuroprotective agents with a multimodal mechanism of action

BP Meloni, FL Mastaglia, NW Knuckey - Frontiers in neurology, 2020 - frontiersin.org
There are virtually no clinically available neuroprotective drugs for the treatment of acute
and chronic neurological disorders, hence there is an urgent need for the development of …

The epidermal keratinocyte as a therapeutic target for management of diabetic wounds

WC Fang, CCE Lan - International Journal of Molecular Sciences, 2023 - mdpi.com
Diabetes mellitus (DM) is an important cause of chronic wounds and non-traumatic
amputation. The prevalence and number of cases of diabetic mellitus are increasing …

Immunomodulatory potential of Nisin A with application in wound healing

MV Mouritzen, A Andrea, K Qvist… - Wound Repair and …, 2019 - Wiley Online Library
Antimicrobial peptides can have a dual role with both antimicrobial activity against a broad
range of bacteria and immunomodulatory effect, making them attractive as therapeutic …

[HTML][HTML] The combination of Synoeca-MP antimicrobial peptide with IDR-1018 stimulates proliferation, migration, and the expression of pro-regenerative genes in both …

T Alencar-Silva, RD Díaz-Martín, A Zonari, D Foyt… - Biomolecules, 2023 - mdpi.com
In skin lesions, the development of microbial infection affects the healing process, increasing
morbidity and mortality rates in patients with severe burns, diabetic foot, and other types of …

Breaking the frontiers of cosmetology with antimicrobial peptides

T Alencar-Silva, MC Braga, GOS Santana… - Biotechnology …, 2018 - Elsevier
Antimicrobial peptides (AMPs) are mostly endogenous, cationic, amphipathic polypeptides,
produced by many natural sources. Recently, many biological functions beyond …

[HTML][HTML] Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota

MV Mouritzen, M Petkovic, K Qvist, SS Poulsen… - … Therapy Methods & …, 2021 - cell.com
Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties; however,
the effects on diabetic wound healing remain poorly understood. The wound healing …