Vitamin D and its therapeutic relevance in pulmonary diseases

S Ahmad, S Arora, S Khan, M Mohsin, A Mohan… - The Journal of …, 2021 - Elsevier
Vitamin D is customarily involved in maintaining bone and calcium homeostasis. However,
contemporary studies have identified the implication of vitamin D in several cellular …

[HTML][HTML] Genomics of Treatable Traits in Asthma

A Espuela-Ortiz, E Martin-Gonzalez, P Poza-Guedes… - Genes, 2023 - mdpi.com
The astounding number of genetic variants revealed in the 15 years of genome-wide
association studies of asthma has not kept pace with the goals of translational genomics …

[HTML][HTML] Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis

M Mohsin, P Singh, S Khan, AK Verma, R Jha… - Scientific reports, 2022 - nature.com
Sepsis has affected millions of populations of all age groups, locations, and sexes
worldwide. Immune systems, either innate or adaptive are dysregulated due to the infection …

[HTML][HTML] Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods

EY Dessie, Y Gautam, L Ding, M Altaye, J Beyene… - Scientific Reports, 2023 - nature.com
Asthma is a heterogeneous respiratory disease characterized by airway inflammation and
obstruction. Despite recent advances, the genetic regulation of asthma pathogenesis is still …

[HTML][HTML] Identification and validation of potential miRNAs, as biomarkers for sepsis and associated lung injury: a network-based approach

S Ahmad, MM Ahmed, PMZ Hasan, A Sharma… - Genes, 2020 - mdpi.com
Sepsis is a dysregulated immune response disease affecting millions worldwide. Delayed
diagnosis, poor prognosis, and disease heterogeneity make its treatment ineffective …

Combined transcriptomics and in-silico approach uncovers the role of prognostic biomarkers in hepatocellular carcinoma

R Solanki, P Singh, MA Beg, R Dohare, AK Verma… - Human Gene, 2023 - Elsevier
Liver cancer is among the top five death-causing malignancies. High mortality rate, poor
prognosis, and minimal drug options for hepatocellular carcinoma (HCC) patients led to the …

TRIM33 Modulates inflammation and airway remodeling of PDGF-BB-induced airway smooth-muscle cells by the WNT/Β-catenin pathway

J Li, X Wang, Y Su, S Hu, J Chen - International archives of allergy and …, 2022 - karger.com
Asthma is a chronic airway disease involving airway inflammation and remodeling. Studies
showed that tripartite motif-containing protein 33 (TRIM33) regulated natural immunity …

[HTML][HTML] Peripheral blood transcriptomic clusters uncovered immune phenotypes of asthma

HW Lee, M Baek, S Choi, YH Ahn, JY Bang… - Respiratory …, 2022 - Springer
Background Transcriptomic analysis has been used to elucidate the complex pathogenesis
of heterogeneous disease and may also contribute to identify potential therapeutic targets by …

The functional role of CST1 and CCL26 in asthma development

A Hoyer, S Chakraborty, I Lilienthal… - Immunity …, 2024 - Wiley Online Library
Background Asthma is the most common chronic disease in children with an increasing
prevalence. Its development is caused by genetic and environmental factors and allergic …

[HTML][HTML] Asthma and post-asthmatic fibrosis: a search for new promising molecular markers of transition from acute inflammation to pulmonary fibrosis

IA Savin, AV Markov, MA Zenkova, AV Sen'kova - Biomedicines, 2022 - mdpi.com
Asthma is a heterogeneous pulmonary disorder, the progression and chronization of which
leads to airway remodeling and fibrogenesis. To understand the molecular mechanisms of …