Delayed puberty (DP) defines a retardation of onset/progression of sexual maturation
beyond the expected age from either a lack/delay of the hypothalamo-pituitary-gonadal axis …

Growth hormone (GH) regulates somatic growth, substrate metabolism and body
composition. Sex hormones exert profound effect on the secretion and action of GH …

Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly
complex process. Here we amalgamate the sparse global evidence and propose three …

There is great interest in therapeutically harnessing endogenous regenerative mechanisms
to increase the number of β cells in people with diabetes. By performing whole‐genome …

This chapter summarizes the intimate relationship between the hypothalamus and the
anterior pituitary with respect to the secretion of ACTH and GH from the physiological …

Objective Reduced bone mineral density (BMD) is seen in Turner syndrome (TS) with an
increased risk of fractures, and body composition is characterized by increased body fat and …

Growth hormone (GH) regulates metabolic and physical health in the adult human. Because
the GH system is regulated by estrogens, therapeutic estrogen compounds are likely to …

The fact that growth hormone (GH) plays an important role in health after the cessation of
growth requiring replacement therapy in adult life has only been recognised in the last three …

Cells that are exposed to harmful genetic damage, either from internal or external sources,
may undergo senescence if they are unable to repair their DNA. Senescence, characterized …

GH deficiency (GHD) in adult patients is a complex condition, mainly due to organic lesion of
hypothalamic-pituitary region and often associated with multiple pituitary hormone …