[HTML][HTML] Brain default-mode network dysfunction in addiction
R Zhang, ND Volkow - Neuroimage, 2019 - Elsevier
Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …
been observed across different classes of substance use disorder (SUD) and are associated …
Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease
J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …
system in age-related episodic memory impairments in humans, with a particular focus on …
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Ketamine's mechanism of action was assessed using gamma power from
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation
We previously demonstrated that network level functional connectivity in the human brain
could be related to levels of inhibition in a major network node at baseline. In this study, we …
could be related to levels of inhibition in a major network node at baseline. In this study, we …
Big GABA: Edited MR spectroscopy at 24 research sites
M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix… - Neuroimage, 2017 - Elsevier
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD),
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
Insulin resistance as a link between amyloid-beta and tau pathologies in Alzheimer's disease
RJ Mullins, TC Diehl, CW Chia… - Frontiers in aging …, 2017 - frontiersin.org
Current hypotheses and theories regarding the pathogenesis of Alzheimer's disease (AD)
heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well …
heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well …
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
SA Meda, G Ruaño, A Windemuth… - Proceedings of the …, 2014 - National Acad Sciences
The brain's default mode network (DMN) is highly heritable and is compromised in a variety
of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and …
of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and …