Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

The emergence and increasing prevalence of multidrug-resistant pathogens has become a
major global healthcare problem. According to the World Health Organization if these trends …

Klebsiella pneumoniae is an opportunistic pathogen belonging to the Enterobacteriaceae
family, which is the leading cause of nosocomial infections. The emergence of hypervirulent …

Two-component systems are ubiquitous signaling mechanisms in bacteria that enable
intracellular changes from extracellular cues. These bacterial regulatory systems couple …

The prevalence of antimicrobial-resistant pathogens significantly limited the number of
effective antibiotics available clinically, which urgently requires new drug targets to screen …

Pseudomonas aeruginosa is an opportunistic pathogen and major cause of hospital-
acquired infections. The virulence of P. aeruginosa is largely determined by its …

While global transcription factors (TFs) have been studied extensively in Escherichia coli
model strains, conservation and diversity in TF regulation between strains is still unknown …

In parallel to the uncontrolled use of antibiotics, the emergence of multidrug-resistant
bacteria, like Acinetobacter baumannii, has posed a severe threat. A. baumannii …