Mitochondrial dysfunction is observed in both the aging brain, and as a core feature of
several neurodegenerative diseases. A central mechanism mediating this dysfunction is …

Clinicians who treat patients with stroke need to be aware of several single-gene disorders
that have ischemic stroke as a major feature, including sickle cell disease, Fabry disease …

Mitochondrial dysfunction is a hypothesized component in the multifactorial pathogenesis of
migraine without aura (MoA,'common migraine') and the related condition of cyclic vomiting …

Mitochondrial background has been demonstrated to influence maximal oxygen uptake
(VO2max, in mLkg− 1min− 1), but this genetic influence can be compensated for by regular …

We hereby propose a novel approach to the identification of ischemic stroke (IS)
susceptibility genes that involves converging data from several unbiased genetic and …

Background and purpose: Recovery after stroke occurs on the basis of specific molecular
events. Genetic polymorphisms associated with impaired neural repair or plasticity might …

Background Genetic factors have a role in the pathogenesis of ischaemic stroke, but the
main genes involved have yet to be defined. Mitochondrial mechanisms have been …

Background Since mitochondria are the principal source of reactive oxygen species (ROS),
these organelles may play an important role in ischemic cardiomyopathy (IC) development …

Mitochondrial dysfunction has been implicated in the pathogenesis of Huntington disease
(HD), a primarily neurodegenerative disorder that results from an expansion in the …

The mitochondria are essential for normal cell functioning. Changes in mitochondrial DNA
(mtDNA) may affect the occurrence of some chronic diseases and cancer. This process is …