Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

[HTML][HTML] On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

EI Vrettos, G Mező, AG Tzakos - Beilstein journal of organic …, 2018 - beilstein-journals.org
Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …

Microbiome in multiple sclerosis: Where are we, what we know and do not know

MK Boziki, E Kesidou, P Theotokis, AFA Mentis… - Brain sciences, 2020 - mdpi.com
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …

Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders

Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …

Kappa free light chains and IgG combined in a novel algorithm for the detection of multiple sclerosis

M Gudowska-Sawczuk, J Tarasiuk, A Kułakowska… - Brain sciences, 2020 - mdpi.com
Background: It is well known that the cerebrospinal fluid (CSF) concentrations of free light
chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS) …

Recent advances in antigen-specific immunotherapies for the treatment of multiple sclerosis

O Kammona, C Kiparissides - Brain Sciences, 2020 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is
considered to be the leading non-traumatic cause of neurological disability in young adults …

[HTML][HTML] S-allyl cysteine improves clinical and neuropathological features of experimental autoimmune encephalomyelitis in C57BL/6 mice

H Zeinali, T Baluchnejadmojarad, S Fallah… - Biomedicine & …, 2018 - Elsevier
Multiple sclerosis (MS) is a deleterious autoimmune and demyelinating disorder of the
central nervous system with debilitating sensory and motor complications. There is still no …

Novel approaches in the immunotherapy of multiple sclerosis: Cyclization of myelin epitope peptides and conjugation with mannan

JM Matsoukas, I Ligielli, CT Chasapis, K Kelaidonis… - Brain sciences, 2021 - mdpi.com
Multiple Sclerosis (MS) is a serious autoimmune disease. The patient in an advanced state
of the disease has restrained mobility and remains handicapped. It is therefore …

Unnatural amino acids improve affinity and modulate immunogenicity: Developing peptides to treat MHC type II autoimmune disorders

D Meister, SM Taimoory, JF Trant - Peptide Science, 2019 - Wiley Online Library
Many autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (RA),
and celiac disease (CD), arise from improper immune system recognition of self or benign …

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

X Ma, J Zhang, Q Jiang, YX Li, G Yang - EBioMedicine, 2025 - thelancet.com
Background Gut commensal microbiota has been identified as a potential environmental risk
factor for multiple sclerosis (MS), and numerous studies have linked the commensal …